Three dimension optical imaging in a high throughput layered expression system

High-throughput imaging of brain gene expression.

Voxelation is a new method for acquisition of three dimensional (3D) gene expression patterns in the brain. It employs high-throughput analysis of spatially registered voxels (cubes) to produce multiple volumetric maps of gene expression analogous to the images reconstructed in biomedical imaging systems. Using microarrays, 24 voxel images of coronal hemisections at the level of the hippocampus...

Determination of experimental Tumor Volume of a mouse using optical imaging system in different processing stages

Thermoelastic Interaction in a Three-Dimensional Layered Sandwich Structure

The present article investigates the thermoelastic interaction in a three-dimensional homogeneous and isotropic sandwich structure using the dual-phase-lag (DPL) model of generalized thermoelasticity. The incorporated resulting non-dimensional coupled equations are applied to a specific problem in which a sandwich layer of unidentical homogeneous and isotropic substances is subjected to time-de...

A High Sensitivity Multi-Spectral Three-Dimensional Fluorescence Optical Tomography System for Small Animal Imaging

We have designed a three dimensional (3D) fluorescence optical tomography system for small animal imaging based on an innovative system geometry that uses a truncated conical mirror which permits the entire surface of the animal to be viewed simultaneously by a single CCD camera. Compared with traditional approaches that employ a flat mirror, the conical mirror system has approximately 3 times ...

High-throughput nonlinear optical microscopy.

High-resolution microscopy methods based on different nonlinear optical (NLO) contrast mechanisms are finding numerous applications in biology and medicine. While the basic implementations of these microscopy methods are relatively mature, an important direction of continuing technological innovation lies in improving the throughput of these systems. Throughput improvement is expected to be imp...